Fig. 1.
NHP safety study designs. (A) Rhesus macaque shedding study. The genome organization of the rVSVIN virus is depicted, and the dose, route of inoculation, and controls for the study are indicated. (B) Cynomolgus macaque NV and neuroinvasiveness studies. The genome organization of each virus or vector is depicted, along with the dose per macaque, route of inoculation, the number of macaques per group, and the day of scheduled euthanasia. (C) Bars indicate sections of cynomolgus macaque brain tissue and spinal cord sections collected at necropsy for histological analysis in the NV and neuroinvasiveness studies. Anatomical regions covered by collected sections are also indicated.