Table 1.
Shedding of infectious virus following IN inoculation of rhesus macaques
| Group | Macaque no.a | Nasal wash |
Saliva |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Day 1 | Day 2 | Day 3 | Day 4 | Day 1 | Day 2 | Day 3 | Day 4 | ||
| rVSVIN | 23 | +b | +/− | − | − | − | − | − | − |
| 48 | +++ | − | − | − | + | − | − | − | |
| 62 | +++ | − | − | − | + | − | − | − | |
| Control | 31 | − | − | − | − | − | − | − | − |
| 24 | − | − | − | − | − | − | − | − | |
a
Macaques 23, 48, and 62 were inoculated IN with 107 PFU of rVSVIN. Macaques 31 and 24 were un-inoculated controls.
b
Infectivity scale: −, no virus detected; +/−, 1–10 PFU/mL; +, 10–100 PFU/mL; ++, 100–1000 PFU/mL; +++, 1000–10,000 PFU/mL.