Table 2.
Study | Route | Group | Day | Geometric mean titera |
---|---|---|---|---|
Shedding | IN | rVSVIN | 8 | < 40 |
14 | 1040 | |||
22 | 1890 | |||
Control | 22 | < 40 | ||
Neuroinvasiveness | IN | wt VSVIN | 21 | 1522 |
rVSVIN | 21 | 2167 | ||
rVSVIN-HIVGag5 | 21 | 1280 | ||
rVSVIN–CT1-HIVGag5 | 21 | < 40 | ||
PBS | 21 | < 40 | ||
Neurovirulence | IT | wt VSVIN | 8 | 226 |
rVSVIN | 8b | 40 | ||
21c | 1280 | |||
rVSVIN-HIVGag5 | 21 | 4305 | ||
rVSVIN-CT1-HIVGag5 | 21 | 80 | ||
PBS | 21 | < 40 |
Titer expressed as reciprocal dilution required to neutralize 100 PFU VSV (limit of detection = 40).
One macaque in this group was euthanized by day 8.
Three macaques in this group survived 21 days.