Table 3.
Daily and group mean clinical scores for cynomolgus macaques inoculated IT
| Group | Macaque no. | Clinical scorea |
|
|---|---|---|---|
| Daily mean | Group mean | ||
| wt VSVIN | 21545Mb | 3 | 3 |
| 22212Mb | 3 | ||
| 22190Fb | 3 | ||
| 16739Fb | 3 | ||
| rVSVIN | 21733M | 0 | 1 |
| 21725M | 1 | ||
| 21789F | 0 | ||
| 21392Fb | 3 | ||
| rVSVIN-HIVGag5 | 19439M | 0 | 0 |
| 22245M | 0 | ||
| 21275F | 0 | ||
| 21578F | 0 | ||
| rVSVIN-CT1-HIVGag5 | 22253M | 0 | 0 |
| 22235M | 0 | ||
| 21797F | 0 | ||
| 21576F | 0 | ||
| PBS | 21724M | 0 | 1 |
| 22238M | 0 | ||
| 22290F | 3c | ||
| 21765F | 0 | ||
a
Clinical scores based on a scale of 0–4, see Materials and methods.
b
Euthanized on day 8 post IT challenge and given a score of 4 for subsequent days.
c
Macaque had head tilt, lethargy, decreased activity, and bilateral pupil dilation on days 1–21, which were considered secondary to the surgical procedures (see Results).