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. 2006 Nov 13;360(1):36–49. doi: 10.1016/j.virol.2006.10.026

Table 6.

Summary of histopathological scores in brain tissue of cynomolgus macaques following IT inoculation

Virus Macaque no. Daya Brain sectionb
 Spinal cord sectionc
BG T C FC OC Mean Cerv Thor Lum Mean
wt VSVIN 22190F 8 4.0d 3.0 2.0 2.0 2.0 2.6 NSe NS NS naf
22212M 8 4.0 4.0 4.0 2.0 2.0 3.2 2.0 2.0 0.0 1.3
16739F 8 2.0 3.0 2.0 1.0 1.0 1.8 0.0 0.0 0.0 0.0
21545M 8 2.0 3.0 2.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0
mean 3.0 3.3 2.5 1.3 1.3 2.3g 0.7 0.7 0.0 0.5h



rVSVIN 21392F 8 2.0 4.0 2.0 2.0 2.0 2.4 NS NS NS na
21733M 21 2.0 2.0 2.0 1.0 1.0 1.6 2.0 3.0 4.0 3.0
21789F 21 4.0 3.0 2.0 2.0 1.0 2.4 2.0 3.0 4.0 3.0
21725M 21 2.0 3.0 2.0 1.0 1.0 1.8 1.0 3.0 2.0 2.0
mean 2.5 3.0 2.0 1.5 1.3 2.1g 1.7 3.0 3.3 2.7g



rVSVIN-HIVGag5 19439M 21 2.0 1.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0
21275F 21 1.0 1.0 1.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0
22245M 21 1.0 1.0 0.0 1.0 1.0 0.8 2.0 1.0 2.0 1.7
21578F 21 2.0 4.0 2.0 1.0 1.0 2.0 1.0 2.0 3.0 2.0
mean 1.5 1.8 0.8 0.5 0.5 1.0i 0.8 0.8 1.3 1.0h



rVSVIN-CT1-HIVGag5 22253M 21 1.0 2.0 1.0 0.0 0.0 0.8 0.0 2.0 0.0 0.7
21797F 21 2.0 3.0 0.0 0.0 2.0 1.4 0.0 2.0 0.0 0.7
22235M 21 1.0 3.0 0.0 1.0 1.0 1.2 0.0 0.0 0.0 0.0
21576F 21 1.0 3.0 2.0 1.0 1.0 1.6 1.0 0.0 1.0 0.7
mean 1.3 2.8 0.8 0.5 1.0 1.3i 0.3 1.0 0.3 0.5h



PBS 21724M 21 1.0 1.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0
22290F 21 0.0 2.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0
22238M 21 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
21765F 21 0.0 1.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0
mean 0.3 1.0 0.0 0.0 0.0 0.3i 0.0 0.0 0.0 0.0h
a

Day of euthanasia.

b

Brain sections: BG, basal ganglia; T, thalamus; C, cerebellum; FC, frontal cortex; OC, occipital cortex (see Fig. 1C).

c

Spinal cord sections: cerv, cervical; thor, thoracic; lum, lumbar (see Fig. 1C).

d

Lesion severity scoring system: 0, no lesions; 1, minimal; 2, moderate; 3, marked; 4, severe.

e

NS, no slide available.

f

na, not applicable.

g

P < 0.01 vs. PBS.

h

P < 0.05 vs. rVSVIN.

i

P ≤ 0.05 vs. wt VSVIN.