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. 2000 Jun 6;97(12):6544–6549. doi: 10.1073/pnas.97.12.6544

Figure 3.

Figure 3

Effect of structure and charge on mobilization by polysaccharides. (A) Mice were injected once (LFuc, HS) or twice (all others) with 50 mg/kg polysaccharides 24 h apart, then bled 3 h after the last injection and evaluated for CFC (bars) or WBC (circles). Control (Ctrl), fucoidan (FCN), linear fucan (LFuc), dextran sulfate (DS), chondroitin sulfate A or B (CSA, CSB), heparan sulfate (HS), dextran (Dex), hyaluronic acid (HA). Number of treated mice is listed within each bar. (B) Control mice (Left, untreated n = 13, FCN alone n = 18) or mice (Right, n = 5 per group) treated with protamine alone (black bars and circles) or cotreated with 100 mg/kg FCN (gray bars and circles). Error bars and statistics as in Fig. 1. *, P < 0.001; **, P < 0.00001.