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. 2007 May 16;2(5):e450. doi: 10.1371/journal.pone.0000450

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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The mutants had a smaller skeleton, abnormal skulls with a domed vault (arrowhead) and protruding incisors (small arrow). Kyphosis (large arrow) of the cervical-thoracic spine was also observed in the mutants. Control, R26^floxneoWnt4 heterozygote; mutant, R26^floxneoWnt4; Col2a1-Cre.