Growth charts and response to treatment for both brothers. A. The proband (I) was diagnosed with constitutional delay of growth and puberty. B. The younger brother (II) was diagnosed with isolated hypogonadotropic hypogonadism. M, maternal height; F, paternal height; FH, final height; Ox, oxandrolone; T, testosterone undecanoate. Upwards arrows indicate start of treatment and downwards arrows indicate treatment discontinuation. C. Endocrine data for the proband (I) showed testosterone values towards the lower part of the normal range (range 287-810 ng/dl; divide by 29 for nmol/l). D. Endocrine data for the younger brother at times when off testosterone treatment; a following hCG 1500iu twice weekly for one month instead of testosterone, b peak following LHRH stimulation, c off testosterone 3 months, d off testosterone 1 year. Growth charts reproduced courtesy of the National Center for Health Science.