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Examples of structure modification of natural products to improve utility as clinical drugs. (A) Modification of rifamycin B to rifampicin to improve pharmacokinetic properties, (B) modification of geldanamycin to 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin to reduce human toxicity and (C) modification of taxol to taxotere to generate a proprietary molecule.
