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. Author manuscript; available in PMC: 2007 May 4.
Published in final edited form as: J Intern Med. 2006 Jan;259(1):91–106. doi: 10.1111/j.1365-2796.2005.01586.x

Fig. 7.

Fig. 7

Markov models of KCNQ1 and IKs channels. Both models contain 15 closed states. Green closed states represent channels in zone 2 that have not completed yet all first transitions of their four voltage sensors. Blue closed states represent channels in zone 1 that have completed first transition of all voltage sensors. (a) KCNQ1 model includes five open states (O1–O5, red) and an inactivated state (I, purple). (b) IKs contains two open states with no inactivation. Reproduced with permission from Silva and Rudy [4].