TABLE 6.
Summary of Results for Individual Factors as Predictors of Cancer Status for Breasts of Women without Pathologic Nipple Discharge1
| Factor Predicting Cancer | N | Sensitivity | Specificity | PPV1 | NPV2 | Accuracy |
|---|---|---|---|---|---|---|
| Palpable | 152 | 59.6 | 40 | 37.4 | 62.3 | 47.4 |
| Age ≥ 49 | 152 | 87.7 | 50.5 | 51.5 | 87.3 | 64.5 |
| Postmenopause | 152 | 82.5 | 43.2 | 46.5 | 80.4 | 57.9 |
| Fewer than 4 Pregnancies | 152 | 77.2 | 29.5 | 39.6 | 68.3 | 47.4 |
| History of BCP Use2 | 152 | 59.6 | 20 | 30.9 | 45.2 | 34.9 |
| History of HRT2 | 152 | 54.4 | 57.9 | 43.7 | 67.9 | 56.6 |
| Family History of Cancer3 | 150 | 29.8 | 80.6 | 48.6 | 65.2 | 61.3 |
| Cytologic Atypia | 152 | 3.5 | 97.9 | 50 | 62.8 | 62.5 |
| Cytologic Cancer | 152 | 3.5 | 100 | 100 | 63.3 | 63.8 |
| PSA < 401 ng/g2 | 81 | 85.7 | 39.1 | 51.7 | 78.3 | 59.3 |
| PSA < 120 ng/g2 | ||||||
| premenopausal subjects | 27 | 50.0 | 66.7 | 30.0 | 82.4 | 63.0 |
| postmenopausal subjects | 54 | 86.2 | 44.0 | 64.1 | 73.3 | 66.7 |
| hK2 ≤ 45 ng/g2 | 75 | 88.6 | 22.5 | 50 | 69.2 | 53.3 |
| bFGF [fourth root ≤ 3 ng/g]2 | 72 | 93.8 | 0 | 42.9 | 0 | 41.7 |
| DNA Index ≥ 1.3 | 38 | 5.9 | 95.2 | 50 | 55.6 | 55.3 |
| S Phase Fraction > 2 | 38 | 64.7 | 47.6 | 50 | 62.5 | 55.3 |
1
: The fraction of false positive samples (1-Specificity) and false negative samples (1-Sensitivity) can be readily calculated.
2
: BCP: birth control pills; bFGF: basic fibroblast growth factor; hK2: human glandular kallikrein 2; HRT: hormone replacement therapy; NPV: negative predictive value; PPV: positive predictive value; PSA: prostate specific antigen
3
: Information was missing regarding family history of breast cancer for two subjects.