Table 1.

The linkage disequilibrium (LD) between all 14 XRCC1 polymorphisms

No	Polymorphisms	1	2	3	4	5	6	7	8	9	10	11	12	13	14
1	EX1-1139 D' (r2)	0.20 (0.13)
2	EX1-1128	0.82 (0.57)	0.22 (0.13)
3	EX1-900	0.92 (0.30)	0.98 (0.39)	0.41 (0.22)
4	EX-128	0.89 (0.27)	0.95 (0.35)	1 (0.93)	0.42 (0.22)
5	EX-52	1 (0.01)	1 (0.01)	1 (0.02)	0.68 (0.02)	0.03 (0.02)
6	Val72Ala	N/A	N/A	N/A	N/A	N/A	0 (0.03)
7	Arg194Trp	1 (0.02)	1 (0.02)	0.97 (0.04)	0.97 (0.04)	1 (0)	N/A	0.06 (0.12)
8	IVS7-33	0.04 (0)	0.05 (0)	0.06 (0)	0.06 (0)	0.15 (0)	N/A	0.13 (0)	0.46 (0.11)
9	Pro206Pro	0.89 (0.24)	0.96 (0.32)	1 (0.83)	0.97 (0.83)	0.39 (0.01)	N/A	0.98 (0.05)	0.06 (0)	0.44 (0.26)
10	Arg280His	0.65 (0)	0.93 (0.01)	0.79 (0.02)	0.74 (0.02)	1 (0)	N/A	1 (0)	1 (0.04)	0.70 (0.02)	0.04 (0.10)
11	Arg399Gln	0.87 (0.11)	0.93 (0.14)	1 (0.39)	0.96 (0.39)	0.04 (0)	N/A	1 (0.04)	0.08 (0)	0.99 (0.47)	1 (0.03)	0.37 (0.23)
12	Gln632Gln	0.86 (0.24)	0.95 (0.32)	0.99 (0.84)	0.91 (0.77)	1 (0.02)	N/A	0.91 (0.04)	0.06 (0)	0.97 (0.90)	0.61 (0.01)	1 (0.45)	0.56 (0.29)
13	EX17-123	0.69 (0.01)	0.76 (0.01)	0.86 (0.03)	0.92 (0.03)	1 (0)	N/A	1 (0)	0 (0)	0.94 (0.04)	0.82 (0)	0.98 (0.03)	0.88 (0.04)	0.06 (0.13)
14	EX17-127	0.69 (0.03)	0.75 (0.04)	0.95 (0.33)	0.96 (0.32)	1 (0.01)	N/A	0.77 (0.01)	0.08 (0)	1 (0.30)	1 (0.01)	1 (0.16)	0.99 (0.31)	0.11 (0)	0.21 (0.09)

Values in bold italics represent the observed followed by estimated (in round bracket) control minor allele frequencies from public databases.

* LD is presented in pairwise D' followed by r² in round bracket.

N/A = Not available because of no pairwise variant genotypes in rare polymorphisms.

Values in bold are polymorphisms in high LD (D' ≥ 0.90and r2 ≥ 0.80).