Table 1.
Enrichment of date hubs for signaling proteins
| MIPS protein classes | Number in date hubs | Total number in hubs | P-value |
|---|---|---|---|
| Small GTP-binding proteins (RAS superfamily) | 4 | 4 | 0 |
| Molecular chaperones | 3 | 4 | 0.02 |
| Protein kinases | 20 | 22 | <1.41E-07 |
| CaMK group | 2 | 2 | 0 |
| CMGC group | 7 | 9 | 0.003 |
| OPG group | 7 | 8 | 0.0005 |
| Unique Saccharomyces cerevisiae kinases | 3 | 3 | 0 |
| Protein phosphatases | 5 | 6 | 0.003 |
| Ubiquitin system proteins | 3 | 3 | 0 |
Date hubs were defined as hubs that have neighborhood EVs greater than 0.3 and avPCC less than 0.45. For protein classes, we used the MIPS (Mewes et al, 2004) protein classification catalogue. Only the classes with most significant P-values are shown. P-values of enrichment were calculated using the cumulative hypergeometric distribution function.