TABLE 1.

Human disease caused by interspecies transmission of avian influenza viruses without prior reassortment

Yr	Antigenic description and interspecies transmission event
Pre-1997	H1N1, 1918 Spanish flu pandemic?
	H7N7, sporadic conjunctivitis
1997	H5N1 in Hong Kong, 18 cases and 6 deaths
1998, 1999, 2003	H9N2 in Hong Kong and Guangdong
2003	H5N1 diagnosed in Hong Kong (likely acquired in Fujian Province, People's Republic of China) and in mainland China
2003	H7N7 in Holland; 78 cases of conjunctivitis, 7 with flu-like illness, 4 others, 1 death
2004	H7N3 in Canada; conjunctivitis
2004-present	H5N1 disease and death in southeast and east Asia, central Asia, the Middle East, and Africa