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. 2007 Apr;14(4):442–450. doi: 10.1128/CVI.00434-06

FIG. 3.

FIG. 3.

Assessment of serum IgG responses to VacA antigens in 174 patients with known H. pylori/VacA statuses. On the ordinate is shown the ratio of the mean OD value of the sample in relation to the seropositivity threshold. Seropositivity is defined as the mean OD from H. pylori-negative patients plus 2 standard deviations. The abscissa divides the population into H. pylori-negative patients and those colonized with m1 or m2 strains. The median value for each group is indicated by a horizontal bar in the scatter plots. (A to C) Assessment of responses of 174 patients (77 H. pylori negative, 32 m1 colonized, and 65 m2 colonized) to cloned VacA antigens P44M1 (A), P48M2 (B), and P55M2 (C). (D, E) Assessment of responses of 141 patients (72 H. pylori negative, 10 m1 colonized, and 59 m2 colonized) after modification to exclude serum samples that have a positive serological response to cloned VacA m1 antigen P44M1. An assessment of modified responses to VacA antigens P48M2 (D) and P55M2 (E) is shown.