TABLE 1.
Concordance and relative sensitivity and specificity of Wampole's AtheNA Multilyte compared to Inova's Quanta Lite EIA and DPC's anti-DNA radioimmunoassay
| AtheNA antigen and result | No. of samples with ELISA result that wasa:
|
Concordance (%) | Relative specificity (%) | Relative sensitivity (%) | |
|---|---|---|---|---|---|
| Positive | Negative | ||||
| SS/A | |||||
| Positive | 187 | 51 | 86.1 | 88.9 | 80.6 |
| Negative | 45 | 408 | |||
| SS/B | |||||
| Positive | 98 | 17 | 93.2 | 97 | 76.6 |
| Negative | 30 | 546 | |||
| Sm | |||||
| Positive | 92 | 29 | 92.8 | 96 | 74.2 |
| Negative | 32 | 688 | |||
| RNP | |||||
| Positive | 160 | 78 | 87.5 | 89.2 | 86.5 |
| Negative | 25 | 563 | |||
| Scl-70 | |||||
| Positive | 63 | 21 | 92.8 | 96.4 | 70 |
| Negative | 27 | 559 | |||
| dsDNA | |||||
| Positive | 215 | 153 | 81 | 77.5 | 91.1 |
| Negative | 21 | 527 | |||
| Centromere B | |||||
| Positive | 113 | 14 | 96.5 | 98 | 88.3 |
| Negative | 15 | 692 | |||
a
dsDNA was analyzed by Farr assay with a cutoff of 5 IU/ml.