TABLE 2.
Performance indices of FC-ALPA-IgG and FC-AFPA-IgG for early cure assessment after chemotherapy in VLa
| IgG and sample time | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Accuracy (%) | LR for PPFP of: |
|
|---|---|---|---|---|---|---|---|
| >50% | ≤50% | ||||||
| FC-ALPA-IgG (1:8,000) | |||||||
| 2 mAT | 100 (85-100) | 38 (21-60) | 61 (45-76) | 100 (67-100) | 86 (72-95) | 1.62 | 0.00* |
| 6 mAT | 100 (85-100) | 100 (85-100) | 100 (85-100) | 100 (85-100) | 100 (91-100) | >10* | 0.00* |
| FC-AFPA-IgG (1:64,000) | |||||||
| 2 mAT | 100 (85-100) | 24 (11-45) | 57 (41-71) | 100 (57-100) | 82 (67-92) | 1.31 | 0.00* |
| 6 mAT | 100 (85-100) | 81 (62-93) | 84 (65-94) | 100 (82-100) | 99 (89-99) | 5.25 | 0.00* |
a
Performance indices are expressed as percentages (with 95% confidence intervals in parentheses), except for LR values, which are expressed as probability ratios.
*
, LR value with high clinical significance.