FIG. 5.

Survival of D. melanogaster infected with C. albicans strain SC5314 is affected by the 4E-BP mutation. Survival of needle-pricked d4E-BP^null virgin flies was compared to the Oregon-R (wild type) and Thor^1rev1 (revertant) flies. (A) The d4E-BP^null male mutant flies were approximately two times more susceptible to the infection with C. albicans during the first 6 h than the wild-type and revertant flies. (B) The d4E-BP^null virgin female flies were 1.5 times more sensitive to the Candida infection than the wild-type and revertant female flies. As a control, d4E-BP^null, Oregon-R, and Thor^1rev1 flies of both genders were pricked with a sterile needle or with a needle coated with S. cerevisiae, which had no effect on the survival rate of Drosophila flies. Survival rates did not change significantly after 6 h. Each data point represents the mean of results from three independent experiments.