TABLE 1.
Genes regulated in S2 cells in the presence of Candida albicans strain SC5314a
| CG no. | FlyBase | Full name | Gene product | Avg fluorescence ratio at time (h):
|
P value (6 h) | |
|---|---|---|---|---|---|---|
| 3 | 6 | |||||
| CG8846 | Thor | d4E-BP1 | eIF4E binding protein | 2.8 | 5.6 | 2.07E−05 |
| CG11335 | lox | Lysyl oxidase | Lysyl oxidase and Scavenger receptor cysteine-rich (SRCR) domains | 1.7 | 4.5 | 0.00532 |
| CG10746 | fok | Fledgling of Kpl38B | 129-amino-acid peptide | 1.7 | 3.3 | 0.0118 |
| CG15009 | ImpL2 | Ecdysone-inducible gene L2 | Cell adhesion, extracellular | 1.5 | 2.6 | 0.00308 |
| CG1600 | Zinc-containing alcohol dehydrogenase superfamily | 1.5 | 2.5 | 0.000133 | ||
| CG7224 | 118-amino-acid peptide | 1.2 | 2.4 | 0.00494 | ||
| CG12389 | Fpps | Farnesyl pyrophosphate synthase | Cholesterol metabolism (EC 2.5.1.1) | 1.5 | 2.2 | 0.000256 |
| CG12818 | 288-amino-acid peptide | 1.5 | 2.1 | 0.00132 | ||
| CG4427 | cbt | Cabut | Transcriptional activator/JNK cascade/autophagy cell death | 1.3 | 1.7 | 0.00253 |
| CG31543 | Hph | HIF prolyl hydroxylase | Oxygen sensor | 1.2 | 1.6 | 0.000776 |
| CG11652 | Diptaminde synthesis domain/diphtheria toxin resistance | 1.3 | 1.6 | 5.03E−05 | ||
| CG17836 | HMG-1, HMGY DNA binding domain/transcription regulation | 1.3 | 1.6 | 0.0286 | ||
| CG9078 | ifc | Infertile crescent | Sphingolipid delta-4 desaturase | 1.3 | 1.6 | 0.0272 |
| CG7741 | Similar to yeast Cwfj/RNA splicing | 1.2 | 1.6 | 2.93E−05 | ||
| CG12317 | JhI-21 | l-Amino acid transporter | 1.3 | 1.6 | 0.00682 | |
| CG10146 | AttA | Attacin-A | Antimicrobial peptide | 1.2 | 1.6 | 0.0322 |
| CG3424 | path | Pathetic | Amino acid/polyamine transporter | 1.2 | 1.5 | 0.0289 |
| CG12358 | Paip2 | Poly(A)-binding protein-interacting protein 2 | Negative regulator of translation | 1.2 | 1.5 | 0.00815 |
| CG3767 | JhI-26 | Juvenile hormone-inducible protein 26 | Putative CHK domain (choline kinase) | 1.2 | 1.5 | 0.0103 |
| CG1882 | Alpha/beta hydrolase flod/aromatic compound metabolism | 1.2 | 1.5 | 0.0106 | ||
| CG17534 | GstE9 | Glutathione S-transferase E9 | Glutathione transferase (EC 2.5.1.18) | 1.2 | 1.5 | 0.0225 |
| CG17533 | GstE8 | Glutathione S-transferase E8 | Glutathione transferase (EC 2.5.1.18) | 1.2 | 1.5 | 0.0608 |
| CG5729 | Dgp-1 | GTP binding domain/putative translation factor | 1.0 | 1.5 | 0.0227 | |
| CG1395 | stg | String | Tyrosine/serine/threonine phosphatase (EC 3.1.3) | −1.3 | −1.8 | 0.000200 |
| CG7670 | 3′-5′ exonuclease and RNase H-like domains | −1.1 | −1.7 | 0.00103 | ||
| CG9552 | rost | Rolling stone | Myoblast fusion | −1.1 | −1.6 | 0.00548 |
| CG30457 | −1.3 | −1.5 | 0.0344 | |||
a
Genes whose expression was either up-regulated (positive values) or down-regulated (negative values) in Candida-treated cells compared to the Candida-free S2 cells at indicated time points.