. 2007 Feb 2;6(4):721–733. doi: 10.1128/EC.00338-06

TABLE 2.

Ascomycete proteins that have orthologs in D. bruxellensis but not S. cerevisiae

Functional class and NCBI accession no.	Species	Gene name	Function
Nitrate metabolism
CAA11229	Hansenula polymorpha	YNT1	Nitrate transporter
CAA11232	Hansenula polymorpha	YNR1	Nitrate reductase
CAA11230	Hansenula polymorpha	YNI1	Nitrite reductase
CAA11231	Hansenula polymorpha	YNA1	Nitrate assimilation pathway-specific Zn(II)₂Cys₆ transcription factor
CAC16081	Hansenula polymorpha	YNA2	Nitrate assimilation pathway-specific Zn(II)₂Cys₆ transcription factor
Metabolism of alternative carbon sources
AAX31178	Candida albicans	NAG1	Glucosamine-6-phosphate deaminase
CAH02587	Kluyveromyces lactis	LAC4	β-Galactosidase
CAE47547	Ambrosiozyma monospora	ALX1	l-Xylulose reductase
CAG88556 ^a	Debaryomyces hansenii		Inositol oxygenase
CAG90181 ^a	Debaryomyces hansenii		Phosphatidylinositol-specific phospholipase C
BAD32688	Hansenula polymorpha		Glycerol dehydrogenase
BAD32689	Pichia ofunaensis		Dihydroxyacetone reductase
Transporters
EAK93787	Candida albicans	HGT1	High-affinity glucose transporter
AAB17122	Debaryomyces occidentalis	HAK1	High-affinity potassium transporter
EAL02606	Candida albicans	NUP	Purine nucleoside permease
EAK96574	Candida albicans	UAP2	Potential purine permease
Lipid metabolism
BAD11952	Saccharomyces kluyveri	FAD3	ω-3 fatty acid desaturase
AAU10084	Pichia pastoris		Δ8-(E)-sphingolipid desaturase
AAU10085	Pichia pastoris		Δ4-(E)-sphingolipid desaturase
AAZ08581	Ashbya gossypii		Sphingolipid C9-methyltransferase
AAK73020	Pichia pastoris		Ceramide glucosyltransferase
Respiratory chain complexes
CAG86996 ^a	Debaryomyces hansenii		Complex I 14-kDa subunit
CAG88782 ^a	Debaryomyces hansenii		Complex I 20-kDa subunit
CAG84577 ^a	Debaryomyces hansenii		Complex I 24-kDa subunit
CAG89146 ^a	Debaryomyces hansenii		Complex I 49-kDa subunit
CAG89064 ^a	Debaryomyces hansenii		Complex I 51-kDa subunit
CAG90271 ^a	Debaryomyces hansenii		Complex I 75-kDa subunit
CAG85893 ^a	Debaryomyces hansenii	AOX1	SHAM-sensitive alternative terminal oxidase 1
Peroxisome
CAA82928	Hansenula polymorpha	PER1	Peroxisomal matrix protein
AAD52811	Hansenula polymorpha	PEX1	Peroxin
P78723	Hansenula polymorpha	PEX14	Peroxin
CAA65646	Pichia pastoris	PEX2	Peroxin
AAF19606	Pichia pastoris	PEX17	Peroxin
AAD43507	Pichia pastoris	PEX19	Peroxin
Other
CAG60540 ^a	Candida glabrata	PRN1	Putative pirin
CAG85416 ^a	Debaryomyces hansenii	URA9	Dihydroorotate dehydrogenase 2
CAG86646 ^a	Debaryomyces hansenii		Beta-alanine synthase
CAH00925 ^a	Kluyveromyces lactis		GTP cyclohydrolase II
CAG80587 ^a	Yarrowia lipolytica		FAD-dependent oxidoreductase
BAB12222	Candida boidinii	DAO1	d-Amino acid oxidase
CAH02585	Kluyveromyces lactis		Acid phosphatase
AAS51137	Ashbya gossypii		Calcineurin-like phosphoesterase
EAL00803	Candida albicans		Potential secreted Cu/Zn superoxide dismutase
EAK95140	Candida albicans		Possible thiamine biosynthesis enzyme
EAL02572 ^a	Candida albicans		Ras GTPase-activating protein
CAG85348 ^a	Debaryomyces hansenii		Potential histone binding protein
CAG78240 ^a	Yarrowia lipolytica		Translation initiation factor 3 subunit 7
EAL04857	Candida albicans		Negative regulator of iron uptake genes
EAK96905	Candida albicans		Potential fungal zinc cluster transcription factor
AAQ75382	Hansenula polymorpha	SWI1	Global transcription activator

For this gene, the best BLAST hit of the D. bruxellensis sequence in the NR database is an unannotated or hypothetical gene, and the functional annotation given here is taken from the highest annotated hit, where the bit score of the annotated hit was at least 90% that of the best hit and sequence comparison indicates that the genes are homologs.