FIG. 6.
Cytokine and chemokine levels in sera from mice orally inoculated with type A F. tularensis. Groups of C57BL/6 mice were orally gavaged with 2 × 107 CFU type A F. tularensis strain FSC033 on day 0, and blood samples were collected at dpi 0, 1, 2, and 3. Cytokine and chemokine levels in the serum were determined by using the Beadlyte mouse multiplex cytokine detection system 2 and mouse chemokine 5-Plex assay kits on a Luminex 100 IS instrument. The data are expressed as means ± the standard deviations of eight mice at each time point. The detection limits of the assays were 2.5 to 5 pg/ml. *, P < 0.05; **, P < 0.01 (versus dpi 0).