TABLE 2.
Shedding of serovar Typhimurium strains in feces of mice following oral inoculationa
| Strain and day postinoculation | Log10 CFU per 100 mg feces for mouseb
|
Mean log10 CFU | ||||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | ||
| MFA25 ΔaroA ΔphoN::aph | ||||||
| 4 | 4.7 | 4.9 | 4.3 | 3.7 | 4.0 | 4.5 |
| 7 | 3.4 | 4.1 | 3.7 | 4.0 | 4.9 | 3.9 |
| 10 | 4.2 | 3.4 | 3.4 | 4.2 | 3.4 | 3.9 |
| 14 | 4.0 | 3.7 | 3.7 | 3.0 | 2.7 | 3.6 |
| MFA25(pTetCnirB15) ΔaroA ΔphoN::aph | ||||||
| 4 | 4.4 | 5.4 | 3.9 | 4.4 | 4.4 | 4.8 |
| 7 | 4.4 | 3.7 | 4.0 | 4.0 | 4.4 | 4.2 |
| 10 | 3.9 | 3.9 | 3.4 | 3.4 | 3.4 | 3.7 |
| 14 | 3.9 | 3.9 | 3.7 | 3.0 | 2.7 | 3.6 |
| MFA13(pTetCnirB15) ΔaroA ΔshdA::aph | ||||||
| 4 | 3.4 | 2.7 | 2.9 | ND | 2.4 | 2.6 |
| 7 | 2.9 | 2.9 | 3.0 | ND | 3.2 | 2.7 |
| 10 | 3.3 | 3.2 | 2.7 | 3.4 | 4.0 | 3.5 |
| 14 | 2.4 | ND | 2.4 | ND | 2.4 | 2.1 |
| MFA12(pTetCnirB15) ΔaroA ΔmisL::cat | ||||||
| 4 | 2.4 | 3.1 | 2.4 | 2.4 | ND | 2.4 |
| 7 | ND | 2.7 | ND | 2.4 | 2.7 | 2.2 |
| 10 | 2.4 | ND | ND | 3.4 | ND | 2.2 |
| 14 | ND | ND | ND | ND | 2.4 | 1.8 |
| MFA17(pTetCnirB15) ΔaroA ΔmisL::cat ΔshdA::aph | ||||||
| 4 | ND | ND | ND | 3.0 | ND | 2.0 |
| 7 | ND | ND | 2.7 | 2.7 | ND | 2.1 |
| 10 | ND | 4.1 | ND | 3.7 | ND | 2.6 |
| 14 | ND | ND | ND | 3.0 | ND | 2.0 |
| MFA16(pTetCnirB15) ΔaroA ΔratB::aph | ||||||
| 4 | 5.4 | 4.7 | 5.0 | 3.9 | 4.7 | 5.0 |
| 7 | 5.5 | 4.4 | 5.7 | 4.7 | 4.4 | 5.3 |
| 10 | 5.4 | 4.7 | 3.7 | 3.7 | 4.1 | 4.8 |
| 14 | 5.4 | 3.7 | 3.0 | 3.0 | 3.4 | 4.7 |
a
Groups of five mice were inoculated orally with serovar Typhimurium MFA25 aroA phoN, serovar Typhimurium MFA25(pTetCnirB15) aro phoN, serovar Typhimurium MFA16(pTetCnirB15) aroA ratB, serovar Typhimurium MFA13(pTetCnirB15) aroA shdA, serovar Typhimurium MFA12(pTetCnirB15) aroA misL, or serovar Typhimurium MFA17(pTetCnirB15) aroA shdA misL.
b
The limit of detection was 50 (log10, 1.7) CFU per sample. ND, not detected.