FIG. 5.

Neutralization of endogenous IL-12 results in decreased IFN-γ production but not decreased IL-4 production. IFN-γ (A) and IL-4 (B) levels were determined by ELISA by using 100 μg of total protein from the supernatant after 24 h of culture of gastric biopsies from the 10 H. pylori-infected patients treated without or with a control IgG antibody (1 μg/ml) or an anti-IL-12 antibody (5 μg/ml). Statistical significance was assessed by ANOVA and Tukey's multiple-comparison tests. Ab, antibody; ns, not significant.