TABLE 3.
Susceptibility of patients with different PIDs to mycobacterial infections
| PID with indicated level of susceptibility: | ||
|---|---|---|
| High | Intermediate | Low |
| Defects of IL-12/IL-23-IFN-γ axisa,b,c (14, 33, 36, 42, 85, 96) | X-linked hyper-IgM syndrome (CD40L deficiency) (66) | Predominantly antibody deficiencies (19, 21, 22, 64, 67, 72, 91) |
| All SCID typesa (11, 12, 105) | Complement deficiencies (43, 107) | |
| Idiopathic CD4 lymphocytopeniab (103) | Neutropenias (9, 25) | |
| Defects of NEMO-dependent NF-κB activation | Leukocyte adhesion deficiencies (LADs) (97) | |
| (X-EDA-ID)b (83) | MHC-I deficiencies (32, 47, 69, 73, 119) | |
| Chronic granulomatous diseasea,c (1, 15, 63, 65, 74) | IRAK-4 deficiency (23, 38, 61, 70, 86, 110) | |
| Asplenia (48, 99) | ||
a
The most frequently isolated mycobacterium with this PID was BCG.
b
The most frequently isolated mycobacterium with this PID was NTM.
c
The most frequently isolated mycobacterium with this PID was M. tuberculosis.