TABLE 6.
Susceptibility of patients with different PIDs to viral infections
| PID with indicated level of susceptibility: | ||
|---|---|---|
| High | Intermediate | Low |
| All forms of SCID (11, 12, 24, 49, 90, 105) MHC-II deficiency (57) Idiopathic CD4 lymphocytopenia (45, 103) Selective NK-cell deficiency (7, 39, 82) Complete STAT-1 deficiency (homozygous patients) (36) ALPS (due to caspase 8 deficiency)d (17) XL- and AR-agammaglobulinemiaa (64, 67, 88) WHIM syndromeb (31, 53) Epidermodysplasia verruciformisb (92) X-linked lymphoproliferative syndromec (62, 75) | IFN-γ receptor defects (13, 34, 78) X-EDA-ID (NEMO defects) (61, 83) CVID (19, 22) X-linked hyper-IgM syndrome (114) Ataxia-telangiectasia syndrome (79) Wiskott-Aldrich syndrome (106) | MHC-I deficiencies due to TAP-1 and TAP-2 defects (32, 47, 69, 73, 119) MHC-I deficiency due to tapasin defectd (115) CD8+ cell deficiencyd (28) Perforin deficiency (41, 71) ALPS (due to Fas, FasL, and caspase 10 defects) (4, 81) IL-12/IL-23 deficiencies (42, 78, 85) IRAK-4 deficiency (23, 38, 61, 70, 86, 110, 116) Chronic granulomatous disease (1, 15, 113) Neutropenias (25, 97) Hyper-IgE syndrome (10, 50, 51) Complement deficiencies (43, 107) Asplenia (48, 99) |
a
Patients with these PIDs are characteristically susceptible to enteroviruses.
b
Patients with this PID are characteristically susceptible to human papillomavirus.
c
Patients with this PID are characteristically susceptible to EBV.
d
Only one case or family has been reported.