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. 2007 Feb 26;75(5):2562–2571. doi: 10.1128/IAI.01656-06

FIG. 2.

FIG. 2.

Surface area of mucosal outgrowth of hyperplastic explants from infected rat MEs. Mucosal explants (all harvested 48 h after bacterial inoculation) were cultured in the presence of various concentrations of C. difficile toxin B (0, 0.1, 1, or 10 ng/ml), CEP11004 (0, 10, 100, or 1,000 nM), or SP600125 (0, 0.2, 2, or 20 μM). The first group for CEP11004 or SP600125 served as a negative control, with the medium receiving a supplement of DMSO alone at 1 μl/ml, the same concentration of DMSO used for all concentrations of CEP11004 and SP600125. (A) With C. difficile toxin B, significant inhibition of growth was observed at 10 ng/ml (P < 0.05). (B) With CEP11004, significant inhibition of growth was observed at 1,000 nM (P < 0.05). (C) With SP600125, significant inhibition of growth was observed at 2 μM and 20 μM (P < 0.05). Values are means ± standard errors (SE) (n = 6 to 10 at each concentration).