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. 2007 Feb 26;75(5):2562–2571. doi: 10.1128/IAI.01656-06

FIG. 5.

FIG. 5.

Average thickness of mucosae in bacterially inoculated guinea pig MEs in vivo. With focal delivery of SP600125, significant local inhibition of both epithelial (A) (*, P < 0.017) and stromal (B) (**, P < 0.018) thickness was observed at 1 mM compared with that in an area 500 μm from the catheter. On the other hand, vehicle (PBS containing 5% DMSO) showed no inhibitory effect on mucosal hyperplasia in the bacterially inoculated guinea pig in vivo. The mean thickness of four healthy mucosal epithelia was 9.95 ± 0.42 μm, and the outer diameter of the microcatheter was 200 μm in our study. Therefore, the bars in the graphs start from 10 μm for epithelium and 200 μm for stroma. Values are means ± SE (n = 7).