TABLE 2.
Genes up-regulated during acute cholera
| Affymetrix ID | Mean log2 ratioa | No. of patientsb | Gene | Gene product | Subcellular localizationc |
|---|---|---|---|---|---|
| 226067_at | 2.81 | 6 | LPLUNC1 | von Ebner minor salivary gland protein | S |
| 202018_s_at | 2.24 | 5 | LF | Lactoferrin | S |
| 226960_at | 1.89 | 6 | VCC1 | VEGFd coregulated chemokine 1 | S |
| 205886_at | 1.77 | 5 | REG1B | Regenerating protein 1β | C |
| 205513_at | 1.69 | 5 | TCN1 | Transcobalamin 1 | S |
| 201925_s_at | 1.64 | 6 | CD55 | CD55 (complement decay accelerating factor) | M |
| 202376_at | 1.64 | 5 | SERPINA3 | α1-Antichymotrypsin | S |
| 1562283_at | 1.56 | 5 | EST (GenBank accession no. BQ889971) | ||
| 204475_at | 1.49 | 5 | MMP1 | Matrix metalloproteinase 1 | S |
| 209519_at | 1.49 | 5 | ESTe (GenBank accession no. BG108193) | ||
| 39402_at | 1.46 | 5 | IL1B | IL-1β | S |
| 205067_at | |||||
| 242592_at | 1.43 | 5 | Hypothetical protein DKFZp762F0713 | ||
| 212531_at | 1.39 | 5 | LCN2 | Lipocalin 2 | S |
| 217678_at | 1.36 | 6 | SLC7A11 | Solute carrier family 7A11 | M |
| 209921_at | |||||
| 242685_at | 1.33 | 5 | Hypothetical protein HSPC135 | ||
| 1557459_at | 1.29 | 5 | cDNA clone (GenBank accession no. AL831884) | ||
| 208473_s_at | 1.27 | 6 | GP2 | Glycoprotein 2 (zymogen granule protein) | S/M |
| 206681_x_at | |||||
| 219795_at | 1.24 | 5 | SLC6A14 | Solute carrier 6A14 | M |
| 206359_at | 1.24 | 5 | SOCS3 | Suppressor of cytokine signaling 3 | C |
| 228058_at | 1.20 | 5 | EST (GenBank accession no. AI559190) | ||
| 221577_x_at | 1.13 | 5 | GDF15 | Growth differentiation factor 15 | S |
| 203021_at | 1.11 | 7 | SLPI | Secretory leukocyte protease inhibitor | S |
| 205242_at | 1.11 | 5 | CXCL13 | Cytokine B13 (B lymphocyte chemoattractant) | S |
| 1559051_s_at | 1.11 | 5 | Hypothetical protein LOC115004 | ||
| 211695_x_at | 1.10 | 6 | MUC1 | Mucin 1 | M |
| 213693_s_at | |||||
| 207847_s_at | |||||
| 205828_at | 1.07 | 7 | MMP3 | Matrix metalloproteinase 3 | S |
| 214135_at | 1.06 | 5 | CLDN18 | Claudin 18 | M |
| 210282_at | 1.04 | 5 | ZNF198 | Zinc finger protein 198 | N |
| 243003_at | 1.04 | 5 | EST (GenBank accession no. AV702197) |
a
The log2 ratios are the acute-phase/convalescent-phase ratios.
b
Number of patients that showed differential expression resulting in a log2 ratio of >0.5.
c
S, secreted; M, membrane associated; C, cytosolic; N, nuclear.
d
VEGF, vascular endothelial growth factor.
e
EST, expressed sequence tag.