TABLE 3.
Genes down-regulated during acute cholera
| Affymetrix ID | Mean log2 ratioa | No. of patientsb | Gene | Gene product | Subcellular localizationc |
|---|---|---|---|---|---|
| 205749_at | −2.73 | 5 | CYP1A1 | Cytochrome P-450, 1A1 | M, Li |
| 238245_at | −1.77 | 6 | ENPP7 | Ectonucleotide pyrophosphatase/phosphodiesterase 7 | M, Li |
| 222938_x_at | −1.74 | 6 | ENPP3 | Ectonucleotide pyrophosphatase/phosphodiesterase 3 | M |
| 244044_at | |||||
| 232737_s_at | |||||
| 204450_x_at | −1.70 | 6 | APOA1 | Apolipoprotein A-I | S, Li |
| 217073_x_at | |||||
| 229725_at | −1.46 | 6 | ACSL6 | Long-chain acyl-coenzyme A synthetase 6 | M, Li |
| 231416_at | −1.46 | 5 | DHDH | Dimeric dihydrodiol dehydrogenase | C |
| 241811_x_at | −1.46 | 6 | ESTd (GenBank accession no. BE645279) | ||
| 205820_s_at | −1.43 | 6 | APOC3 | Apolipoprotein C-III | S, Li |
| 244014_x_at | −1.41 | 5 | EST (GenBank accession no. BF433962) | ||
| 239229_at | −1.41 | 6 | EST (GenBank accession no. AI342246) | ||
| 1555338_s_at | −1.40 | 6 | AQP10 | Aquaporin 10 | M |
| 242009_at | −1.36 | 6 | EST (GenBank accession no. AI082692) | ||
| 204561_x_at | −1.34 | 7 | APOC2 | Apolipoprotein C-II | S, Li |
| 1552279_a_at | −1.30 | 6 | Hypothetical protein FLJ00234 | ||
| 206292_s_at | −1.23 | 6 | SULT2A1 | Alcohol sulfotransferase | C, Li |
| 206293_at | |||||
| 223579_s_at | −1.21 | 6 | APOB | Apolipoprotein B | S, Li |
| 224412_s_at | −1.21 | 5 | TRPM6 | Transient receptor potential cation channel M6 | M |
| 228377_at | −1.20 | 5 | KLHL14 | Kelch-like 14 | |
| 210096_at | −1.17 | 5 | CYP4B1 | Cytochrome P-450, 4B1 | M, Li |
| 227480_at | −1.16 | 6 | SUSD2 | Sushi domain containing 2 | M |
| 207519_at | −1.16 | 7 | SLC6A4 | Solute carrier family 6A4 | M |
| 1553486_a_at | −1.16 | 6 | Hypothetical protein FLJ39647 | ||
| 1556250_at | −1.16 | 5 | ST18 | Suppression of tumorigenicity 18 | N |
| 223732_at | −1.13 | 6 | SLC23A1 | Solute carrier 23A1 | M |
| 207885_at | −1.09 | 5 | S100G | Calbindin D9k | C |
| 220851_at | −1.09 | 5 | Hypothetical protein PRO1600 | ||
| 207378_at | −1.06 | 5 | TREH | Trehalase (brush border membrane glycoprotein) | M |
| 229793_at | −1.06 | 6 | EST (GenBank accession no. AI656964) | ||
| 1552362_a_at | −1.06 | 5 | LEAP-2 | Liver-expressed antimicrobial peptide 2 | S |
| 205939_at | −1.04 | 5 | CYP3A7 | Cytochrome P-450, 3A7 | M, Li |
| 207362_at | −1.04 | 5 | SLC30A4 | Solute carrier family 30A4 | M |
| 207125_at | −1.01 | 5 | ZNF225 | Zinc finger protein 225 | N |
| 1558703_at | −1.00 | 6 | Hypothetical protein DKFZp451K1917 |
a
The log2 ratios are the acute-phase/convalescent-phase ratios.
b
Number of patients that showed differential expression resulting in a log2 ratio of <0.5.
c
S, secreted; M, membrane associated; C, cytosolic; N, nuclear; Li, involved in the metabolism or transport of lipids.
d
EST, expressed sequence tag.