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CD4+ T-cell proliferative responses to rCTP, rVirB9, and rVirB10. Two-week T-cell lines enriched for CD4+ T cells from animal 04B90 (A), 04B91 (B), or 04B92 (C) were cultured for 4 days with 0.1, 1, or 10 μg per ml of the indicated antigen, radiolabeled, and harvested. Results are presented as the mean cpm ± 1 SD for duplicate cultures. Statistical significance of a response compared to that for medium or negative-control antigen is indicated by an asterisk where the P value is ≤0.05.
