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. 2007 Mar 5;75(5):2120–2125. doi: 10.1128/IAI.01781-06

FIG. 4.

FIG. 4.

Concurrent activity of ET and LT on DBA/2J lethality. Animals received an intravenous injection of 1 μg (n = 10), 5 μg (n = 10), 10 μg (n = 15), or 15 μg ET (n = 10), immediately followed by an intraperitoneal injection of 100 μg LT. Control animals (n = 10) received one injection in which individual components were omitted: 15 μg PA plus 100 μg LT, 15 μg EF plus 100 μg LT, or 15 μg ET plus 100 μg PA. By the log rank test, the groups given 10 μg ET plus 100 μg LT (P = 0.0027) and 5 μg ET plus 100 μg LT (P = 0.00315) were significantly different from the 15 μg PA plus 100 μg LT group. The groups given 1 μg ET plus 100 μg LT (P = 0.5842) and 15 μg ET plus 100 μg LT (P = 0.0699) were not significantly different from the group given 15 μg PA plus 100 μg LT, although the latter group (15 μg ET) was statistically significant from the other two control groups (P < 0.05).