TABLE 1.
Ocular disease severity scores for the scarification and 6-h-healing murine models of P. aeruginosa keratitis after inoculation with ∼1 × 103 CFU strain 6206 in 5 μl of MEM (control) or human tear fluid (diluted 1:2 in MEM)a
| Time (h) | Disease severity scores
|
|||
|---|---|---|---|---|
| Scarification model
|
6-h-healing model
|
|||
| Control | With tear fluid | Control | With tear fluid | |
| 24 | 3, 3, 3, 3, 3 | 1, 2, 0, 0, 0 | 2.5, 2, 2.5, 3, 3 | 0, 0, 0, 0, 0 |
| 48 | 3, 3, 3, 3, 3 | 2.5, 2.5, 0, 0, 0 | 2.5, 2.5, 2.5, 3, 3 | 0, 0, 0, 0, 0 |
a
The disease scores (as defined in Materials and Methods) for eyes treated with tear fluid were significantly lower than the disease scores for controls at each time in each model (P = 0.005, as determined by the Mann-Whitney test).