TABLE 1.
Patient | Isolate no. | Site of isolationb | Area of origin | Date of isolation (day/mo/yr)b | Biofilm productiond | Susceptibility (MIC [μg/ml]) to indicated antifungal
|
||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Amphotericin | Fluconazole | Itraconazole | Ketoconazole | 5-Flucytosine | Voriconazole | Caspofungin | ||||||
P1 | CP25 | Nail | Pisa (Italy) | 16/08/2004 | A | 0.03 | 4 | 0.125 | 0.06 | 0.06 | 0.03 | 0.25 |
P2 | CP47 | Skin | Pisa (Italy) | 05/09/2004 | A | 0.03 | 2 | 0.125 | 0.06 | 0.03 | 0.03 | 0.125 |
P3 | CP85a | Catheter | L'Aquila (Italy) | U | A | 0.06 | 8 | 0.25e | 0.25 | 0.125 | 0.06 | 0.25 |
P4 | CP125 | Nail | Pisa (Italy) | 01/05/2005 | A | 0.03 | 1 | 0.06 | 0.06 | 0.06 | 0.06 | 0.125 |
P5 | CP185a | Blood | Varese (Italy) | U | A | 0.125 | 4 | 0.125e | 0.125 | 0.125 | 0.06 | 1 |
P6 | CP287a | Toenail | Hong Kong | U | A | 16 | 0.125 | 0.125 | 0.06 | 0.06 | 0.06 | 0.25 |
P7 | CP288a | Nail | Belgium | U | A | 0.03 | 4 | 0.125 | 0.06 | <0.03 | 0.03 | 0.125 |
P8 | CP289a | U | NCPFc (United Kingdom) | U | A | 0.06 | 8 | 0.25e | 0.25 | >64f | 0.06 | 0.25 |
P9 | CP296 | Skin | Pisa (Italy) | U | A | 0.03 | 2 | 0.06 | 0.03 | 0.03 | 0.03 | 0.125 |
P10 | CP331 | Sputum | Pisa (Italy) | 16/01/2006 | A | 0.125 | 2 | 0.125 | 0.06 | 0.06 | 0.03 | 0.5 |
P11 | CP344 | Catheter | Pisa (Italy) | 09/01/2006 | A | 0.03 | 2 | 0.125 | 0.06 | <0.03 | 0.016 | 0.125 |
P12 | CP124 | Bronchial aspirate | Pisa (Italy) | 02/05/2005 | A | 0.03 | 8 | 0.25e | 0.125 | 0.03 | 0.06 | 0.125 |
P12 | CP128 | Wound | Pisa (Italy) | 16/05/2005 | A | 0.03 | 8 | 0.25e | 0.06 | 0.06 | 0.03 | 0.125 |
P12 | CP133 | Bronchial aspirate | Pisa (Italy) | 19/05/2005 | A | 0.06 | 8 | 0.25e | 0.125 | 0.06 | 0.06 | 0.25 |
P12 | CP134 | Bronchial aspirate | Pisa (Italy) | 23/05/2005 | A | 0.03 | 8 | 0.25e | 0.125 | 0.03 | 0.06 | 0.125 |
P12 | CP135 | Bronchial aspirate | Pisa (Italy) | 26/05/2005 | A | 0.03 | 8 | 0.25e | 0.125 | 0.03 | 0.06 | 0.125 |
P12 | CP136 | Bronchial aspirate | Pisa (Italy) | 30/05/2005 | A | 0.06 | 8 | 0.25e | 0.125 | 0.06 | 0.06 | 0.25 |
P12 | CP137 | Urine | Pisa (Italy) | 06/06/2005 | A | 0.06 | 8 | 0.25e | 0.125 | 0.06 | 0.06 | 0.25 |
P12 | CP138 | Bronchial aspirate | Pisa (Italy) | 06/06/2005 | A | 0.06 | 8 | 0.125 | 0.125 | 0.06 | 0.06 | 0.25 |
P12 | CP139 | Skin | Pisa (Italy) | 06/06/2005 | A | 0.06 | 8 | 0.25e | 0.125 | 0.06 | 0.06 | 0.25 |
P12 | CP140 | Blood | Pisa (Italy) | 10/06/2005 | A | 0.06 | 8 | 0.25e | 0.125 | 0.06 | 0.06 | 0.25 |
P12 | CP141 | Blood | Pisa (Italy) | 11/06/2005 | A | 0.03 | 4 | 0.125 | 0.05 | 0.03 | 0.03 | 0.125 |
P12 | CP142 | Bronchial aspirate | Pisa (Italy) | 09/06/2005 | A | 0.06 | 4 | 0.125 | 0.06 | 0.06 | 0.03 | 0.125 |
P12 | CP143 | Bronchial aspirate | Pisa (Italy) | 13/06/2005 | A | 0.03 | 4 | 0.125 | 0.06 | 0.06 | 0.03 | 0.125 |
P12 | CP144 | Urine | Pisa (Italy) | 13/05/2005 | A | 0.03 | 4 | 0.125 | 0.06 | 0.03 | 0.03 | 0.125 |
P12 | CP145 | Urine | Pisa (Italy) | 20/06/2005 | A | 0.03 | 4 | 1.125 | 0.06 | 0.06 | 0.03 | 0.125 |
P12 | CP227 | Urine | Pisa (Italy) | 17/06/2005 | A | 0.03 | 4 | 0.125 | 0.06 | 0.06 | 0.03 | 0.125 |
P12 | CP230 | Urine | Pisa (Italy) | 04/07/2005 | A | 0.03 | 8 | 0.25e | 0.125 | 0.06 | 0.06 | 0.125 |
P12 | CP234 | Urine | Pisa (Italy) | 11/07/2005 | A | 0.03 | 8 | 0.25e | 0.125 | 0.03 | 0.06 | 0.125 |
P12 | CP242 | Urine | Pisa (Italy) | 18/07/2005 | A | 0.03 | 16e | 0.25e | 0.5 | 0.06 | 0.125 | 0.125 |
P13 | CP269 | Bronchial aspirate | Pisa (Italy) | 05/09/2005 | A | 0.06 | 4 | 0.125 | 0.125 | 0.06 | 0.06 | 0.25 |
P13 | CP268 | Bronchial aspirate | Pisa (Italy) | 08/09/2005 | A | 0.06 | 4 | 0.125 | 0.125 | 0.03 | 0.06 | 0.125 |
P13 | CP273 | Bronchial aspirate | Pisa (Italy) | 12/09/2005 | A | 0.06 | 4 | 0.125 | 0.125 | 0.03 | 0.06 | 0.25 |
Strains CP85 (originally named HEM22), CP185 (originally OSVE-L075), and CP287 to CP289 (originally J960679/2, J950813, and 81/026) were kindly provided by E. Pontieri, G. Morace, and F. C. Odds, respectively.
U, unknown.
NCPF, The National Collection of Pathogenic Fungi.
A, absent.
Dose-dependently susceptible.
Resistant.