TABLE 2.
Clinical and virological features of patients in different HBV clinical groups
| Characteristic | Value for disease group
|
P valuea | ||
|---|---|---|---|---|
| CH (n = 132) | LC (n = 32) | HCC (n = 47) | ||
| Mean age ± SD (yr) | 30.0 ± 9.1 | 50.2 ± 12.0 | 49.8 ± 11.6 | <0.001 |
| Sex (no. of males/no. of females) | 108/24 | 26/6 | 42/5 | 0.461 |
| No. (%) of HBeAg-positive patients | 94 (71.2) | 10 (31.3) | 8 (17.0) | <0.001 |
| Liver function indicators (mean ± SD) | ||||
| ALT (U/liter) | 201.7 ± 202.5 | 146.7 ± 183.7 | 63.9 ± 41.6 | <0.001 |
| AST (U/liter) | 117.1 ± 121.3 | 142.5 ± 141.9 | 74.2 ± 60.4 | 0.023 |
| ALB (g/liter) | 46.1 ± 4.9 | 34.7 ± 3.1 | 38.3 ± 4.6 | <0.001 |
| TBIL (μmol/liter) | 13.9 ± 6.7 | 51.4 ± 20.5 | 35.4 ± 28.5 | <0.001 |
| No. (%) of patients with viral mutation(s): | ||||
| C1653T | 2 (1.5) | 1 (3.1) | 9 (19.1) | <0.001 |
| T1753V | 13 (9.8) | 6 (18.8) | 25 (53.2) | <0.001 |
| A1762T G1764A | 44 (33.3) | 18 (56.3) | 40 (85.1) | <0.001 |
| 1856T | 17 (12.9) | 4 (12.5) | 9 (19.1) | 0.554 |
| 1858T | 100 (75.8) | 25 (78.1) | 24 (51.1) | 0.004 |
| 1896A | 36 (27.3) | 6 (18.8) | 17 (36.2) | 0.233 |
| 1898A | 2 (1.5) | 1 (3.1) | 8 (17.0) | 0.001 |
| 1899A | 7 (5.3) | 4 (12.5) | 10 (21.3) | 0.006 |
a
P values are between values for CH, LC, and HCC patient groups.