TABLE 5.

Genes induced in both HeLa/16E6 cells and fibroblasts

Fold induction in E6 cellsa	Fold induction in fibroblastsb	Entrez gene no.	Gene symbol	Description	Classc
7.9	2.0	22890	ZBTB1	Zinc finger and BTB domain containing 1
7.9	4.4	8334	HIST1H2AC	Histone 1, H2ac
4.4	2.1	440533	PSG8	Pregnancy-specific beta-1-glycoprotein 8
3.8	2.7	427	ASAH1	N-Acylsphingosine amidohydrolase (acid ceramidase)	L
3.5	2.3	6840	SVIL	Supervillin	CB
3.2	2.3	2247	FGF2	Fibroblast growth factor 2 (basic)	CJ
3.1	2.1	26060	APPL	Adaptor protein, pH and PTB domains, leucine zipper motif
3.0	2.3	84140		cDNA FLJ13305 fis, clone OVARC1001399
2.7	6.9	23766	GABARAPL3	GABA(A) receptors associated protein like 3
2.6	2.6	134145		Chromosome 5 clone CTD-2199O4
2.5	2.5	390	RND3	Rho family GTPase 3
2.5	3.8	440449		Hypothetical gene supported by AF086204
2.5	2.3	51706	CYB5R1	Cytochrome b5 reductase 1	ET, TA
2.5	3.8	718	C3	Complement component 3	CP
2.5	2.1	57088	PLSCR4	Phospholipid scramblase 4	TA, CB
2.3	2.1	26020	LRP10	Low-density lipoprotein receptor-related protein 10
2.3	2.5	51449	PCYOX1	Prenylcysteine oxidase 1	L, O
2.3	2.3	9052	RAI3	Retinoic acid-induced 3
2.2	3.5	7474	WNT5A	Wingless-type mouse mammary tumor virus integration site family, member 5A
2.2	2.5	81533	ITFG1	Integrin alpha FG-GAP repeat containing 1
2.2	2.2	64065	PERP	TP53 apoptosis effector; p53-induced protein PIGPC1
2.1	7.2	23710	GABARAPL1	GABA(A) receptor-associated protein-like 1
2.1	2.3	5654	PRSS11	Protease, serine, 11 (IGF binding)	P
2.1	2.2	2745	GLRX	Glutaredoxin (thioltransferase)	CJ, ET, TA
2.1	2.4	1601	DAB2	Disabled homolog 2, mitogen-responsive phosphoprotein
2.1	2.8	114294	LACTB	Lactamase, beta
2.0	2.5	1026	CDKN1A	Cyclin-dependent kinase inhibitor 1A (p21, Cip1)

^aInduction in E6 cells 6 days after expression of the E2 protein compared to mock infection.

^bInduction in senescent fibroblasts compared to proliferating fibroblasts.

^cL, lysosomal; CB, calcium binding; CJ, c-jun target; ET, electron transport activity; TA, transporter activity; CP, complement pathway; O, oxidoreductase activity; P, protease.