TABLE 3.
Dynamically regulated host genes involved in JAK/STAT signaling pathway in BCBL-1 cells early during HIV-1 Tat transfection
| Gene function and name | Accession no. | Fold change at time posttransfection
|
|||
|---|---|---|---|---|---|
| 3 h | 6 h | 12 h | 24 h | ||
| Jak and Stat proteins | |||||
| JAK1 | NM_002227 | 32.53 | 1.38 | 5.37 | 1.71 |
| JAK2 | NM_004972 | 2.03 | 1.04 | 1.69 | 2.42 |
| JAK3 | NM_000215 | 2.74 | 1.05 | 1.25 | 2.94 |
| Stat1 | NM_007315 | 1.12 | 0.93 | 1.38 | 1.31 |
| ISGF-3 | NM_005419 | 0.87 | 1.00 | 1.24 | 0.87 |
| Stat3 | NM_003150 | 1.28 | 1.04 | 1.99 | 1.38 |
| Stat4 | NM_003151 | 0.93 | 1.61 | 3.27 | 0.88 |
| MGF | NM_003152 | 2.37 | 9.47 | 9.74 | 0.90 |
| Stat5 | NM_012448 | 2.30 | 10.72 | 4.40 | 0.89 |
| Stat6 | NM_003153 | 1.52 | 1.22 | 1.98 | 1.37 |
| Tyk2 | NM_003331 | 0.91 | 6.44 | 2.54 | 0.87 |
| Receptors that bind and activate Jak proteins | |||||
| FMS/CD115 | NM_005211 | 2.13 | 1.05 | 1.90 | 2.54 |
| IL-3Rβ | NM_000395 | 5.91 | 1.38 | 2.65 | 0.94 |
| EGFR | NM_005228 | 1.33 | 1.14 | 0.99 | 1.57 |
| EPOR | NM_000121 | 1.60 | 11.21 | 0.92 | 0.89 |
| IFN-αR1 | NM_000629 | 1.85 | 17.50 | 0.70 | 0.89 |
| IFN-αR2 | NM_000874 | 3.29 | 14.30 | 0.69 | 0.90 |
| IFN-γR-1 | NM_000416 | 18.48 | 1.36 | 2.45 | 1.26 |
| IFN-γR-2 | NM_005534 | 14.58 | 1.60 | 1.17 | 1.23 |
| IL-2Rr | NM_000206 | 10.74 | 1.18 | 3.17 | 2.36 |
| gp130 | NM_002184 | 2.40 | 4.75 | 0.59 | 0.89 |
| IL-10Rα | NM_001558 | 12.18 | 1.29 | 0.78 | 1.17 |
| IL-10Rβ | NM_000628 | 6.89 | 1.34 | 1.02 | 2.09 |
| IL-20Rα | NM_014432 | 4.59 | 3.62 | 0.86 | 1.14 |
| IL-22R | NM_021258 | 1.99 | 11.13 | 1.01 | 0.90 |
| TPOR | NM_005373 | 1.39 | 2.71 | 1.76 | 0.89 |
| Nuclear factors and coactivators that interact with Stat proteins | |||||
| C/EBPβ | NM_005194 | 2.07 | 1.24 | 2.18 | 0.89 |
| CBP | NM_004380 | 10.61 | 1.28 | 1.23 | 1.50 |
| CRKL | NM_005207 | 2.42 | 2.14 | 1.09 | 0.90 |
| HMGIY | NM_145904 | 1.62 | 2.01 | 0.68 | 1.52 |
| p48/IRF9 | NM_006084 | 1.34 | 0.99 | 0.91 | 1.58 |
| v-jun | NM_002228 | 1.20 | 1.00 | 0.98 | 1.29 |
| Smad1 | NM_005900 | 1.94 | 2.05 | 0.36 | 0.88 |
| Smad2 | NM_005901 | 2.56 | 3.38 | 0.74 | 1.71 |
| Smad3 | NM_005902 | 2.32 | 1.34 | 0.96 | 1.56 |
| Smad4/DPC4 | NM_005359 | 0.60 | 4.71 | 20.11 | 0.88 |
| Smad5 | NM_005903 | 1.24 | 0.98 | 3.82 | 0.88 |
| Smad6 | NM_005585 | 2.14 | 1.02 | 1.22 | 3.08 |
| Smad7 | NM_005904 | 2.82 | 1.19 | 1.34 | 2.11 |
| Smad9 | NM_005905 | 0.92 | 1.61 | 1.05 | 0.87 |
| CDC46 | NM_006739 | 1.71 | 1.12 | 0.85 | 1.88 |
| NCOA1 | NM_003743 | 0.56 | 0.77 | 0.72 | 0.87 |
| KBF1 | NM_003998 | 0.97 | 2.27 | 1.11 | 1.20 |
| NMI | NM_004688 | 1.46 | 1.29 | 1.03 | 1.16 |
| SH2B | NM_015503 | 1.10 | 7.24 | 2.41 | 0.87 |
| Sp1 | XM_028606 | 2.74 | 1.65 | 7.49 | 1.60 |
| PU.1 | NM_003120 | 1.29 | 7.88 | 3.46 | 0.88 |
| c-src | NM_005417 | 1.11 | 1.08 | 1.78 | 1.27 |
| STAM | NM_003473 | 0.67 | 1.97 | 2.10 | 0.87 |
| STUB1 | NM_005861 | 1.54 | 1.21 | 8.84 | 1.16 |
| USF1 | NM_007122 | 0.61 | 1.87 | 3.46 | 0.86 |
| YY1 | NM_003403 | 2.85 | 1.52 | 1.31 | 1.03 |
| Genes induced by Stat proteins | |||||
| Induced by Stat1 | |||||
| MIG | NM_002416 | 1.94 | 1.23 | 1.10 | 2.05 |
| INDO | NM_002164 | 1.24 | 0.96 | 0.83 | 1.28 |
| IRF-1 | NM_002198 | 2.10 | 2.63 | 1.44 | 8.28 |
| CIITA | NM_000246 | 1.04 | 1.36 | 1.04 | 0.88 |
| NOS | NM_000625 | 0.62 | 1.35 | 1.45 | 0.78 |
| Induced by Stat3 | |||||
| A2M | NM_000014 | 5.42 | 1.21 | 3.73 | N/A |
| Bcl-x | NM_138578 | 1.71 | 1.09 | 2.86 | 1.77 |
| P21/Waf1/CIP1 | NM_000389 | 11.88 | 2.53 | 1.46 | 1.03 |
| CRP | NM_000567 | 1.01 | 1.02 | 0.86 | 1.04 |
| IRF-1 | NM_002198 | 2.10 | 2.63 | 1.44 | 8.28 |
| Jun-B | NM_002229 | 1.17 | 0.95 | 0.95 | 1.20 |
| Transin | NM_002422 | 2.38 | 1.13 | 2.42 | 1.91 |
| c-Myc | NM_002467 | 0.83 | 13.17 | 1.10 | 0.87 |
| SSI-1/Cish1 | NM_003745 | 0.87 | 0.99 | 0.78 | 0.90 |
| Fas/Apo-1/CD95 | NM_000043 | 0.71 | 14.87 | 4.15 | 0.88 |
| Induced by Stat4 | |||||
| CD23 | NM_002002 | 2.22 | 1.58 | 0.97 | 1.57 |
| FcGR1 | NM_000566 | 2.92 | 1.07 | 1.36 | 2.15 |
| IFN-γ | NM_000619 | 1.01 | 4.33 | 6.99 | 0.88 |
| IRF-1 | NM_002198 | 2.10 | 2.63 | 1.44 | 8.28 |
| c-Myc | NM_002467 | 0.83 | 13.17 | 1.10 | 0.87 |
| Induced by Stat5 | |||||
| Cyclin D1 | NM_053056 | 18.44 | 1.79 | 1.68 | 1.05 |
| P21/Waf1/CIP1 | NM_000389 | 11.88 | 2.53 | 1.46 | 1.03 |
| β-Casein | NM_001891 | 8.55 | 1.59 | 1.35 | 0.95 |
| CD25 | NM_000417 | 0.82 | 2.10 | 4.52 | 0.87 |
| IRF-1 | NM_002198 | 2.10 | 2.63 | 1.44 | 8.28 |
| OSM | NM_020530 | 1.83 | 1.00 | 1.83 | 1.67 |
| Pim-1 | NM_002648 | 0.91 | 1.04 | 0.73 | 0.93 |
| Induced by Stat6 | |||||
| FcER1 | NM_002001 | 1.35 | 1.28 | 1.01 | 1.48 |
| GATA3 | NM_002051 | 23.14 | 1.29 | 1.63 | 1.15 |
| IgHG3 | AI950854 | 37.18 | 1.39 | 1.14 | 1.27 |
| IL-4 | NM_000589 | 5.52 | 5.09 | 3.96 | 6.25 |
| IL-4Rα | NM_000418 | 2.12 | 2.20 | 2.01 | 8.82 |
| c-Maf | NM_005360 | 2.00 | 1.10 | 0.74 | 1.52 |
| Induced by Stat1/Stat1/p48 | |||||
| GBP1 | NM_002053 | 2.39 | 9.17 | 1.54 | 0.90 |
| Induced by Stat1/Stat2/p48 (ISGF3) | |||||
| IFI616 | NM_002038 | 29.77 | 1.21 | 3.87 | 1.38 |
| ISG15 | NM_005101 | 1.31 | 1.03 | 1.02 | 1.50 |
| INDO | NM_002164 | 1.24 | 0.96 | 0.83 | 1.28 |
| OAS1 | NM_002534 | 1.29 | 0.98 | 2.10 | 1.63 |
| Negative regulators of the Jak/Stat pathway | |||||
| PIASX-β | NM_004671 | 1.17 | 1.02 | 2.61 | 1.39 |
| DDXBP1 | NM_016166 | 3.59 | 1.08 | 1.93 | 2.46 |
| PIAS3 | NM_006099 | 0.85 | 1.13 | 1.21 | 0.88 |
| PIASy | NM_015897 | 0.78 | 0.91 | 1.12 | 0.72 |
| PTP-1β | NM_002827 | 0.96 | 0.94 | 0.90 | 0.95 |
| PTPNS1 | NM_080792 | 0.38 | 1.58 | 1.14 | 0.84 |
| Cd45 | NM_002838 | 2.63 | 1.39 | 12.78 | 1.76 |
| SSI-1/Cish1 | NM_003745 | 0.87 | 0.99 | 0.78 | 0.90 |
| StatI2 | NM_003877 | 1.13 | 1.03 | 1.20 | 1.31 |
| SSI-3 | NM_003955 | 1.76 | 1.15 | 1.09 | 1.29 |
| SOCS6/CIS4 | NM_004232 | 1.45 | 1.06 | 0.92 | 1.33 |
| SOCS5 | NM_144949 | 0.74 | 4.17 | 1.74 | 0.88 |
| SOCS4 | NM_080867 | 0.96 | 0.98 | 1.89 | 0.97 |