FIG. 1.

rM51R-M virus infection upregulates the expression of genes associated with all three apoptotic pathways. L929 cells were mock infected or infected with rWT virus or rM51R-M virus. At 16 h postinfection, total RNA was harvested and subjected to oligonucleotide microarray analysis. Microarrays were analyzed as described in Materials and Methods. Data are expressed as a ratio of the signal level in virus-infected cells to the level in mock-infected cells and coded as induced (red), suppressed (green), or unchanged (yellow). Gray indicates signal levels that were not significantly different from the background signal of the nonspecific control probe set. (A) Genes associated with death receptor apoptotic pathways. (B) Genes associated with the mitochondrial apoptotic pathway. (C) Genes associated with endoplasmic reticulum stress-induced apoptosis. TNFR, tumor necrosis factor receptor.