FIG. 5.

Effect of TNFR1 deficiency on H5N1 virus disease outcome. B6/129 and TNFR1-deficient mice were infected with 1,000 MID₅₀ of HK/483 or HK/486 virus. (A and B) Ten mice were observed for weight loss (A) and survival (B) for 14 days p.i. Data are expressed as a percentage of mean starting weight or total survival. (C and D) Four mice from each virus-infected group were euthanized on either day 3 (C) or day 6 (D) p.i., and viral titers of individual tissues were determined. Data are expressed as log₁₀ of mean viral titers ± SE. *, P ≤ 0.001; **, P ≤ 0.02.