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. 2006 Dec 20;81(6):2831–2837. doi: 10.1128/JVI.02157-06

FIG. 2.

FIG. 2.

Tg1D4(Prnpo/o) mice develop spontaneous disease but not scrapie. A. The earliest symptom in cyPrP-expressing mice was scratching behavior (pruritis). Note the loss of fur around the neck and forelimb as a result of persistent scratching. B. Fifteen Tg1D4(Prnpo/o) mice and 13 Tg1D4(Prnp+/+) mice were monitored for signs of spontaneous disease, and results were plotted as Kaplan-Meier survival curves. Survival was not significantly different from that of Tg1D4(Prnp+/+) mice (χ2 = 1.47; P = 0.24). C. Six non-Tg and nine Tg1D4(Prnpo/o) mice were monitored for signs of scrapie and 1D4 phenotype following intracerebral inoculation of 2.5% RML isolate of mouse-passaged scrapie, and results were plotted as survival curves. None of the Tg1D4(Prnpo/o) mice developed signs of scrapie, but they did develop signs typical of the 1D4 phenotype.