TABLE 1.

Time to disease for all experiments

Mouse line	Inoculum	Ns/Nta	Phenotype	Incubation period (days) ± SE
Tg1D4(Prnpo/o)		13/13	Scratching, some ataxia	512 ± 14
Tg1D4(Prnp+/+)		15/15	Scratching, some ataxia	498 ± 27
Non-Tg	RML	6/6	Severe ataxia, hunched	151 ± 1.6
Tg1D4(Prnpo/o)	RML	0/9	Scratching, some ataxia	Not sickd
Non-Tg	BHb (Tg2D1)	0/13	Normal	Not sick, >800
Non-Tg	cyPrP (N2a)	0/6	Normal	Not sick, >800
Non-Tg	cyPrP-PI (N2a)	0/6	Normal	Not sick, >800
Non-Tg	Mock (N2a)	0/5	Normal	Not sick, >800
Non-Tg	RMLc	5/5	Severe ataxia, hunched	167 ± 1.0

^aN_s/N_t, number sick/number tested.

^bBH, brain homogenate.

^cRML inoculum prepared separately.

^dNo symptoms of typical mouse scrapie.