TABLE 1.
Mouse line | Inoculum | Ns/Nta | Phenotype | Incubation period (days) ± SE |
---|---|---|---|---|
Tg1D4(Prnpo/o) | 13/13 | Scratching, some ataxia | 512 ± 14 | |
Tg1D4(Prnp+/+) | 15/15 | Scratching, some ataxia | 498 ± 27 | |
Non-Tg | RML | 6/6 | Severe ataxia, hunched | 151 ± 1.6 |
Tg1D4(Prnpo/o) | RML | 0/9 | Scratching, some ataxia | Not sickd |
Non-Tg | BHb (Tg2D1) | 0/13 | Normal | Not sick, >800 |
Non-Tg | cyPrP (N2a) | 0/6 | Normal | Not sick, >800 |
Non-Tg | cyPrP-PI (N2a) | 0/6 | Normal | Not sick, >800 |
Non-Tg | Mock (N2a) | 0/5 | Normal | Not sick, >800 |
Non-Tg | RMLc | 5/5 | Severe ataxia, hunched | 167 ± 1.0 |
Ns/Nt, number sick/number tested.
BH, brain homogenate.
RML inoculum prepared separately.
No symptoms of typical mouse scrapie.