FIG. 7.

HBc_18-27 T-cell recognition of naturally infected hepatocytes. (A) Phenotypes of chronically HBV infected hepatocytes from two individual patients. (B) HBc_18-27-specific T-cell clone degranulation and IFN-γ production after incubation alone with HLA-A2⁺ uninfected, with HLA-mismatched HBV infected, or with HLA-A2⁺ HBV-infected PHH. (C) Graphical representation of CD107a and IFN-γ data from panel B (Exp 1) and an additional experiment with HLA-A2⁺, chronically HBV-infected PHH (Exp 2). A2+ and A2− on the x axis indicate whether PHH were used for the experiment.