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Neutralization of influenza virus occurs by a process that is independent of C5-mediated viral lysis. Sera (30%) from mice with a spontaneous mutation in C5 (−/−) were used in a VN assay. Sera from C5-sufficient mice (+/+) were used as positive controls. C5-deficient serum was also heat inactivated (HI) to demonstrate that the virus-neutralizing activity of this serum was dependent on complement. The horizontal line indicates the level of stock PR8 virus used in the assay.
