TABLE 2.
Prechallenge ELISPOT responsesa
| Macaque group | Response to antigen
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tat
|
Nef
|
Gag
|
Env
|
|||||||||
| Peak (mean) | Responders (%) | Frequency (mean %) | Peak (mean) | Responders (%) | Frequency (mean %) | Peak (mean) | Responders (%) | Frequency (mean %) | Peak (mean) | Responders (%) | Frequency (mean %) | |
| I (Ad Tat) | 124 | 87.5 | 25 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| II (Ad Tat/Env) | 28 | 62.5 | 20 | NA | NA | NA | NA | NA | NA | 1,005 | 100 | 56 |
| III (Ad Tat/Env/Gag/Nef) | 45 | 75 | 17 | 115 | 100 | 23 | 380 | 100 | 53 | 1,946 | 100 | 58 |
a
Peak, mean of peak positive responses, weeks 0 to 50; responders, percentage of macaques exhibiting a positive response, weeks 0 to 50; frequency, mean of frequency of positive responses for each macaque over the eight time points evaluated, weeks 0 to 50; NA, not applicable.