TABLE 3.
Prechallenge proliferative responsesa
| Macaque group | Response to antigen
|
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tat
|
Nef
|
p27
|
gp140
|
Ald-SHIV
|
|||||||||||
| Peak (mean SI) | Responders (%) | Freq. (mean %) | Peak (mean SI) | Responders (%) | Freq. (mean %) | Peak (mean SI) | Responders (%) | Freq. (mean %) | Peak (mean SI) | Responders (%) | Freq. (mean %) | Peak (mean SI) | Responders (%) | Freq. (mean %) | |
| I (Ad Tat) | 5.3 | 87.5 | 14.3 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| II (Ad Tat/Env) | 10.2 | 50 | 37.5 | NA | NA | NA | NA | NA | NA | 7.6 | 62.5 | 25 | 3.4 | 100 | 23.4 |
| III (Ad Tat/Env/Gag/Nef) | 6.5 | 75 | 22.9 | 24.2 | 87.5 | 19.6 | 9.7 | 50 | 21.9 | 11.1 | 75 | 22.9 | 8.0 | 87.5 | 46.4 |
a
Peak, mean of peak positive responses, weeks 0 to 50; responders, percentage of macaques exhibiting a positive response, weeks 0 to 50; Freq., mean of frequency of positive responses for each macaque over the eight time points evaluated, weeks 0 to 50; NA, not applicable.