TABLE 1.
Baseline participant characteristics by response group
| Feature | Value for patients with:
|
P | ||
|---|---|---|---|---|
| Marked response | Intermediate response | Poor response | ||
| No. | ||||
| Total | 27 | 17 | 25 | |
| AA | 13 (48%) | 9 (53%) | 11 (44%) | 0.85a |
| Male | 17 (63%) | 14 (82%) | 19 (76%) | 0.33a |
| Body wt (kg) | ||||
| Mean (SD) | 84.7 (22.5) | 92.1 (23.4) | 93.1 (14.6) | 0.28b |
| Median (25th, 75th) | 79.8 (70.8, 97.1) | 94.3 (81.2, 99.8) | 93.9 (79.8, 104.3) | |
| HCV RNA level (log10 IU/ml) | ||||
| Mean (SD) | 6.0 (0.8) | 6.5 (0.6) | 6.4 (0.5) | |
| Median (25th, 75th) | 5.7 (5.3, 6.8) | 6.7 (6.2, 6.9) | 6.4 (6.2, 6.6) | 0.11c |
| ALT (mg/dl) | ||||
| Mean (SD) | 101.7 (94.1) | 69.5 (28.7) | 129.8 (106.3) | |
| Median (25th, 75th) | 68.0 (42.0, 123.0) | 65 (52.0, 81.0) | 83.0 (58.0, 164.0) | 0.13c |
| Liver histology | ||||
| Ishak necroinflammatory score (0-18) | ||||
| Mean (SD) | 8.2 (2.6) | 7.2 (2.4) | 7.8 (3.3) | |
| Median (25th, 75th) | 8 (6, 9) | 8 (6, 9) | 7 (5, 9) | 0.48c |
| Ishak fibrosis score (0-6) | ||||
| Mean (SD) | 2.1 (1.0) | 1.7 (1.3) | 2.4 (1.4) | |
| Median (25th, 75th) | 2 (1, 3) | 1 (1, 2) | 2 (2, 3) | 0.08c |
a
Chi-square test.
b
Analysis of variance.
c
Kruskal-Wallis test.