TABLE 1.

Coreceptor usage of sequential HIV-1 isolates and of V1-V3 clones from dualtropic isolates

Patient	Time from infection (mo)a	Phenotype of isolate	No. of clones using coreceptor(s)b:			No. of inactive clonesc
			CCR5	CCR5 and CXCR4	CXCR4
1865	49	R5	10
	55	R5	9
	61	R3X4			10
	70	R3X4			10
2239	25	R5	8
	45	R5	10
	68	R5X4	1	0	7	1
	79	R5X4	0	0	10	0
	88	R5X4	4	0	4	2
2242	18	R5	10
	45	R5	8
	56	R5	9
	63	R5	10
	63	R5	9
	64	R5	10
	76	R5X4	1	0	0	9
	84	R5X4	7	0	1	2
	85:1d	R5X4	5	0	3	1
	85:2e	R5X4	5	0	3	2
2282	10	R5	10
	21	R5	8
	24	R5	7
	41	R5	10
	47	R5X4	3	3	0	3
	62	R5X4	3	5	0	1
	63	R5X4	2	2	4	1
	70	R5X4	1	3	4	2

^aTime from infection was calculated as the midpoint between the last negative sample and the first positive sample.

^bCoreceptor usage of chimeric viruses was determined by infection of U87.CD4 cells expressing CCR5 or CXCR4.

^cChimeric viruses that did not infect CCR5- or CXCR4-expressing cells.

^dFirst sample, 85 months postinfection.

^eSecond sample, 85 months postinfection.