FIG. 8.

Proinflammatory cytokines IL-6 (A) and IFN-γ (B) in the lungs after virus challenge. Lung extracts were prepared on day 4 postchallenge. Naïve mouse samples were used as controls. Cytokines in lung extracts were determined by ELISAs, and results shown are geometric mean values obtained from six mice at each time point. Immunization groups (40 μg VLP, 10 μg VLP, and M1 VLP) are described in the legend to Fig. 2, and PR8 and WSN denote a challenge infection with PR8 and WSN, respectively.