FIG. 1.

(A) Schematic showing single units of the KSHV TR and the sequence of the minimal replicator element (RE-LBS1/2). (B) Theoretical models of DNA replication. Solid lines, parental (original) DNA; shaded lines, newly synthesized DNA. In a conservative mode of replication, the original DNA molecule remains intact and generates a completely new molecule with H:H density in the presence of a density label. In a dispersive DNA replication mode, the two DNA molecules are generated with sections of both old and new DNA interspersed along each strand. In semiconservative DNA replication, the replicated DNA molecule is composed of one old and one new strand, thus yielding a molecule with intermediate density (H:L) after one round, which becomes H:H and H:L after the second round of replication.