FIG. 6.

Critical role of type I IFNs in innate immune responses to adenoviral vectors. Ad-lacZ was injected intravenously into WT or IFN-αβR^−/− (IFN-αβR^−/−) 129/Sv mice. (A) Six hours later, sera were measured for IL-6 and IL-12. (B) Two or 72 h later, total genomic DNA was isolated from the liver and analyzed for adenoviral genome copies by quantitative real-time PCR. Data represent adenoviral copies per μg of total genomic DNA.