Table 1.
List of Genes Identified by Angle Selection
| Gene ID | Ratio of means | Loading | Gene description |
|---|---|---|---|
| Liver-specific signature | PC1 | ||
| M36803 | 213.5 | 0.3293 | hemopexin |
| J02843 | 337.8 | 0.3284 | cytochrome P450IIE1 (ethanol-inducible) |
| X53595 | 344.5 | 0.318 | β-2-glycoprotein I (apolipoprotein H) |
| HG2841-HT2970 | 197.3 | 0.3175 | albumin 5 |
| HG2841-HT2969 | 161.5 | 0.3042 | albumin, 3 |
| M13149 | 131.5 | 0.2592 | histidine-rich glycoprotein |
| M10050 | 291.6 | 0.2533 | liver fatty acid binding protein (FABP) |
| X03168 | 2313.7 | 0.2242 | S-prot |
| D14446 | 148.2 | 0.2113 | HFREP-1 |
| M16961 | 161.2 | 0.2067 | α-2 HS-glycoprotein α and β chain |
| X51441 | 342.2 | 0.1958 | serum amyloid A (SAA) protein clone pAS3-α |
| HG1827-HT1856 | 284.2 | 0.1956 | cytochrome P450, subfamily Iic |
| L00190 | 254.4 | 0.1614 | D29832, M21642 and others |
| M58600 | 1225.6 | 0.1523 | heparin cofactor II (HCF2) |
| M21642 | 183.9 | 0.1265 | (dysfunctional) antithrombin III (ATIII) Utah |
| M19828 | 1577.6 | 0.1064 | apolipoprotein B-100 (apoB) |
| M11567 | 3034.8 | 0.1059 | angiogenin and three Alu repetitive sequences |
| X14690 | 222.4 | 0.1045 | plasma inter-α-trypsin inhibitor heavy chain H(3) |
| M21642 | 128.9 | 0.096 | (dysfunctional) antithrombin III (ATIII) Utah |
| M20786 | 248.8 | 0.0929 | α-2-plasmin inhibitor |
| M11321 | 317.2 | 0.0881 | group-specific component vitamin D-binding protein |
| U08006 | 146.8 | 0.0855 | complement 8 α subunit (C8A) |
| J03474 | 132.6 | 0.0778 | transcription factor SP1 |
| S48983 | 358.8 | 0.0771 | SAA4 (serum amyloid A) |
| Muscle-specific signature | PC1 | ||
| X00371 | 545 | 0.3348 | myoglobin |
| M33772 | 1527.7 | 0.3083 | fast skeletal muscle troponin C |
| Z20656 | 2992.5 | 0.287 | cardiac α-myosin heavy chain |
| M21494 | 410.4 | 0.2863 | muscle creatine kinase (CKMM) |
| U96094 | 363.6 | 0.279 | sarcolipin (SLN) |
| J04760 | 701.8 | 0.2658 | slow-twitch skeletal troponin I (TNN1) |
| M83308 | 5723.7 | 0.2651 | mitochondrial cytochrome-c oxidase subunit VIa (COX6A) |
| X06825 | 452.3 | 0.2444 | skeletal β-tropomyosin |
| L21715 | 851.7 | 0.2257 | troponin I fast-twitch isom |
| M21665 | 488.5 | 0.2184 | β-myosin heavy chain |
| M19309 | 1149.9 | 0.2099 | slow skeletal muscle troponin T, clone H22h |
| X90568 | 3169.9 | 0.2077 | titin protein (clone hh1-hh4) |
| S73840 | 350.5 | 0.2022 | type Hx myosin heavy chain |
| M20543 | 993.2 | 0.1917 | skeletal α-actin |
| X16504 | 1016.3 | 0.168 | X51957 and others |
| M20642 | 747.2 | 0.15 | alkali myosin light chain 1 |
| U35637 | 386.9 | 0.1345 | nebulin/U35637 |
| M29458 | 564.4 | 0.1056 | carbonic anhydrase III |
| M86407 | 759.1 | 0.0813 | α actinin 3 (ACTN3) |
| Brain-specific signature | PC2 | ||
| S72043 | 90.4306 | 0.4026 | GIF (growth inhibitory factor) |
| M13577 | 686.2963 | 0.3566 | myelin basic protein (MBP) |
| S40719 | 20.5566 | 0.2755 | glial fibrillary acidic protein |
| HG1877-HT1917 | 82.2133 | 0.1778 | myelin basic protein |
| X99076 | 49.5985 | 0.1633 | NRGN |
| U48437 | 23.3006 | 0.1404 | amyloid precursor-like protein 1 |
| J04615 | 5.9926 | 0.1292 | lupus autoantigen (small nuclear ribonuclepoprotein snRNP SM-D) |
| D21267 | 184.849 | 0.1252 | highly expressed protein |
| L07807 | 30.2311 | 0.1162 | dynamin |
| HG3437-HT3628 | 27.4526 | 0.1159 | myelin proteolipid protein |
| L10373 | 18.2544 | 0.1123 | (clone CCG-B7) sequence |
| M16364 | 9.3301 | 0.1071 | creatine kinase-B |
| M98539 | 3.7109 | 0.0912 | prostaglandin D2 synthase |
| U44839 | 3.1469 | 0.089 | putative ubiquitin C-terminal hydrolase (UHX1) |
| D63851 | 10.9002 | 0.0863 | unc-18 homolog |
| Y09836 | 16.17 | 0.0838 | unknown protein |
| M37457 | 9.0757 | 0.0805 | Na+, K+, ATPase catalytic subunit alpha-III isoform |
| M25667 | 27.35 | 0.0779 | neuronal growth protein 43 (GAP-43) |
| D78577 | 6.3676 | 0.0779 | DNA for 14-3-3 protein eta chain |
| L20814 | 68.1413 | 0.0735 | glutamate receptor 2 (HBGR2) |
| J04046 | 6.4909 | 0.0729 | calmodulin |
| X04741 | 137.5351 | 0.0719 | protein product (PGP) 95 |
| L37033 | 6.0028 | 0.071 | FK-506 binding protein homolog (FKBP38) |
| M11749 | 11.5785 | 0.0669 | Thy-1 glycoprot |
| D82343 | 140.3644 | 0.0649 | AMY |
| S82024 | 47.6237 | 0.06 | SCG10 (neuron-specific growth-associated protein/stathmin homolog) |
| D49958 | 29.5755 | 0.0571 | membrane glycoprotein M6 |
| M65066 | 15.0292 | 0.0541 | cAMP-dependent protein kinase regulatory subunit RI-β |
| D87465 | 9.7149 | 0.0532 | KIAA0275 |
| X86809 | 4.3215 | 0.0524 | major astrocytic phosphoprotein PEA-15 |
The genes are sorted by their loadings on the projection space (PC), which separates the specific tissue. Also provided is the ratio of the mean of the gene expression in the specific tissue sample to the mean of the gene expression in all the other tissues. Genes with large values of the ratio tend to have large PC loadings. In the case of the brain-specific signature, only the top 30 genes as ranked by their loads on PC 2 are provided. A complete list of genes is in Supplementary Materials.